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Malignant pleural mesothelioma (MPM) is a rare and aggressive form of cancer. Timely diagnosis and treatment are required to improve outcomes. Confirming the diagnosis of MPM can be challenging; therefore, we developed a novel screening system based on serological tests and ultrasound-guided thoracic needle biopsy (TNB) to detect MPM. We evaluated the feasibility of the screening system using an artificial pleural effusion containing human cholangiocarcinoma. The study protocol was approved by the institutional review board. We obtained informed consent from patients before their enrollment in this study. A total of 50 patients with hyperbilirubinaemia and other signs of cholangiocarcinoma were enrolled in the study. Serum was obtained, and pleural effusion was collected using centrifugation. We evaluated the concordance between the diagnosis based on the screening test and the final diagnosis of MPM by immunohistochemical staining of pleural tissue. In addition, the feasibility of TNB, which was performed when necessary, was assessed. Among the 50 patients, 15 were confirmed with MPM and five were diagnosed with benign diseases after TNB. The sensitivity, specificity, and accuracy of this screening system was 87.0%, 81.8%, and 84.0%, respectively. TNB was performed when necessary. Using this screening system, we successfully diagnosed eight patients with MPM. The screening system was considered feasible for the detection of MPM and TNB could be done when necessary.Q:

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The recipe for a dream home may be simple — find a house, fix it up, make it your own — but when it comes to houses on wheels, a dream home is a lot more complex. Basically, anything with wheels is a towable, and with a towable comes more equipment and more potential problems.

“A towable has more stuff — more electrical, gas, steering, braking, hydraulic, suspension, brake, all those things,” says Mike Schmitt, vice president of internal affairs at G & B Towing. “Plus, you’re also dealing with corrosion, so that’s a whole other slew of problems.

“Plus, you have the weight issue, which takes a lot of work to get that kind of thing towed,” Schmitt says. “A towable is pretty heavy.”

In honor of the slew of towable-related problems, G&B Towing in Wilkes-Barre is offering a class on towable maintenance and repair.

The class, entitled “RV Maintenance and Repair,” is presented by Mike Schmitt and Bobby McClelland of G & B Towing. It will be held 7:30 p.m. Aug. 8 at the Wilkes-Barre Cultural Center, 140 Washington St.

The class is open to the public and costs $25.

“It’s just meant to be an overview,” Schmitt says. “We want people to understand how these things work.”

The class covers many topics, including towable chassis structure, electrical system, safety, and travel.

“Most towables are kind of ‘jury-rigged’ and not very well constructed,” says Schmitt. “You have to understand the chassis and how it works and just kind of figure it out from there. Then it’s getting in and working on all the little stuff, things like brakes, steering, suspension.”

Schmitt says that over the years G & B has worked on many towables in Wilkes-Barre and in the surrounding areas.

“A lot of people don’t have the time, money, or abilities
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This report illustrates the case of a patient with a complex ocular inflammatory condition. The patient presented with bilateral chronic anterior uveitis with peripheral iris synechiae and intractable intermediate uveitis resistant to numerous immunosuppressive agents. Although the patient had a history of multiple coagulopathies, he had a normal coagulant workup. The vitreous showed a non-infectious, retinal vasculitis. The peripheral retina was edematous. Systemic examination was negative for connective tissue disease. Infectious mononucleosis was diagnosed by positive viral polymerase chain reaction test on peripheral blood and a positive Epstein-Barr virus early antigen test. When left untreated, progressive iris synechiae and macular edema occurred. Treatment with intraocular steroids and antimetabolites led to a dramatic improvement in both eyes. Uveitis and macular edema resolved and the patient became free from inflammation. This report discusses a multisystemic inflammatory condition seen in a patient with posterior scleritis, anterior uveitis, and serositis. Prompt diagnosis is of paramount importance for the appropriate management of this condition.Treatment of malignant ascites with doxorubicin.
Malignant ascites is a therapeutic challenge because it often complicates advanced malignancy, resulting in an emaciated and debilitated patient who is often noncompliant. Doxorubicin, used in other malignancies, may be an effective agent for the treatment of malignant ascites because of its specific cytotoxicity and its effectiveness in mesothelioma. However, the authors’ experience and a review of the literature have shown that, in most cases, high-dose doxorubicin is less than therapeutically effective. When indwelling access tubes are utilized, the authors suggest that indwelling access tubes be left in place for 1 week after doxorubicin administration, allowing the fall in ascites volume to take place. This will also

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